期刊
HUMAN IMMUNOLOGY
卷 65, 期 11, 页码 1297-1306出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.humimm.2004.09.004
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资金
- NIAID NIH HHS [AI25210-18, AI55234-02] Funding Source: Medline
Alloantigen specific CD8(+)CD28(-) T suppressor (T-S) cells differ from naturally occurring CD4(+)CD25(+) T-regulatory (natural T-R) cells not only by their phenotype but also by their mechanism of action. Natural T-R have been extensively studied, leading to the identification of characteristic molecular markers such as Forkhead box P3 (FOXP3), glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4). We have investigated the expression of these genes in alloantigen specific T-S and CD4(+)CD25(+) T regulatory (T-R) cells and found that they are expressed at levels similar to those observed in natural TR. Furthermore, similar to natural CD4(+)CD25(+) TR, antigen-specific CD8(+)CD28(-)CD62L(+) Ts cells have more suppressive capacity than CD8(+)CD28(-)CD62L(-) Ts cells. In spite of these similarities, natural TR are not antigen-specific and inhibit other T cells by T cell-to-T cell interaction, whereas T-S are antigen-specific and exert their inhibitory function by interacting with antigen-presenting cells and render them tolerogenic to other T cells. The molecular characterization of T-S cells may contribute to a better understanding of mechanisms involved in inhibition of immune responses in autoimmunity, transplantation, and chronic viral infection. (C) American Society for Histocompatibility and Immunogenetics, 2004. Published by Elsevier Inc.
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