期刊
NATURE NEUROSCIENCE
卷 7, 期 11, 页码 1195-1203出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1332
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资金
- NINDS NIH HHS [R01 NS15429-24A1] Funding Source: Medline
Neuronal migrations along glial fibers provide a primary pathway for the formation of cortical laminae. To examine the mechanisms underlying glial-guided migration, we analyzed the dynamics of cytoskeletal and signaling components in living neurons. Migration involves the coordinated two-stroke movement of a perinuclear tubulin 'cage' and the centrosome, with the centrosome moving forward before nuclear translocation. Overexpression of mParalpha disrupts the perinuclear tubulin cage, retargets PKCzeta and gamma-tubulin away from the centrosome, and inhibits centrosomal motion and neuronal migration. Thus, we propose that during neuronal migration the centrosome acts to coordinate cytoskeletal dynamics in response to mParalpha-mediated signaling.
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