Metabolites of the marine fungus Humicola fuscoatra KMM 4629

A new sesquiterpene of the caryophyllene series, fuscoatrol A (1), and known compounds, 11-epiterpestacin (2) and beta-nitropropionic acid (3), were isolated from the marine fungus Humicola fuscoatra (Traaen) KM M 4629 associated with the Kuril colonial ascidium. The structure of 1 was established on the basis of X-ray diffraction data and 2D NMR spectroscopy. The antimicrobial and cytotoxic activities of compounds 1-3 were studied.