期刊
NATURE IMMUNOLOGY
卷 5, 期 11, 页码 1149-1156出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/ni1122
关键词
-
类别
资金
- NCI NIH HHS [CA84500] Funding Source: Medline
- NHLBI NIH HHS [HL62348, HL69507] Funding Source: Medline
- NIAID NIH HHS [AI26322, AI39671] Funding Source: Medline
The range of regulatory T cell (T-R cell) types that control immune responses is poorly understood. We describe here a population of T-R cells that developed in vivo from naive CD4(+)CD25(-) T cells during a T helper type 1 (T(H)1)-polarized response, distinct from CD25(+) T-R cells. These antigen-specific T-R cells were induced by CD8alpha(+) DCs, produced both interleukin 10 and interferon-gamma, and potently inhibited the development of airway hyper-reactivity. These T-R cells expressed the transcription factors Foxp3 and T-bet, indicating that these T-R cells are related to T(H)1 cells. Thus, adaptive T-R cells are heterogeneous and comprise T(H)1-like T-R cells as well as previously described T(H)2-like T-R cells, which express Foxp3 and are induced during the development of respiratory tolerance by CD8alpha(-) DCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据