期刊
APPLIED PHYSICS LETTERS
卷 97, 期 16, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3500820
关键词
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资金
- National Institutes of Health [R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, 5P60 DK02057933]
- Microphotoacoustics, Inc.
- Endra, Inc.
Picosecond absorption relaxation-central to many disciplines-is typically measured by ultrafast (femtosecond or picosecond) pump-probe techniques, which however are restricted to optically thin and weakly scattering materials or require artificial sample preparation. Here, we developed a reflection-mode relaxation photoacoustic microscope based on a nanosecond laser and measured picosecond absorption relaxation times. The relaxation times of oxygenated and deoxygenated hemoglobin molecules, both possessing extremely low fluorescence quantum yields, were measured at 576 nm. The added advantages in dispersion susceptibility, laser-wavelength availability, reflection sensing, and expense foster the study of natural-including strongly scattering and nonfluorescent-materials. (C) 2010 American Institute of Physics. [doi:10.1063/1.3500820]
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