期刊
JOURNAL OF COMBINATORIAL CHEMISTRY
卷 6, 期 6, 页码 862-868出版社
AMER CHEMICAL SOC
DOI: 10.1021/cc049900s
关键词
-
A novel and highly diverse tagged triazine library incorporating a triethylene glycol-based linker was synthesized using an orthogonal combinatorial approach on the solid phase and covalently immobilized on a glass substrate as a small molecule microarray (SMM). The SMM was screened with a fluorophore-conjugated human IgG, and 4 novel binders from a library of 2688 compounds were identified from the fully spatially addressable array without the need for compound decoding. Using surface plasmon resonance (SPR) analysis, binding seen on the array was confirmed, and a binding constant as low as K-d = 2.02 x 10(-6) M was measured.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据