期刊
JOURNAL OF VIROLOGY
卷 78, 期 21, 页码 12058-12061出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.78.21.12058-12061.2004
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资金
- NIAID NIH HHS [R01AI50111, R01 AI050111, R37 AI029873] Funding Source: Medline
- PHS HHS [R01 50466] Funding Source: Medline
APOBEC3G is promiscuous with respect to its antiretroviral effect, requiring that it be packaged into diverse retrovirus particles. Here, we show that most virally encoded human immunodeficiency virus type 1 particle components are dispensable for APOPEC3G incorporation. However, replacement of the nucleocapsid (NC) Gag domain with a leucine zipper abolished APOBEC3G incorporation. Moreover, coprecipitation analysis showed that APOBEC3G-Gag interaction requires NC and nonspecific RNA. These observations suggest that APOBEC3G exploits an essential property of retroviruses, namely, RNA packaging, to infiltrate particles. Because it is, therefore, difficult to evolve specific sequences that confer escape from APOBEC3G, these findings may explain why lentiviruses evolved an activity that induces its destruction.
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