期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 19, 期 11, 页码 1892-1904出版社
WILEY
DOI: 10.1359/JBMR.040701
关键词
osteoblast; growth hormone; Runx2/Cbfa1; protein-protein interaction; Stat3 beta
We document that GH controls osteoblast function by modulating the biological activity of the osteospecific transcription factor Runx2. Evidence is provided for a physical interaction between Runx2 and Stat3beta, which is enhanced by GH and downregulates the transcriptional properties of this key osteogenic regulator.
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