期刊
INTERNATIONAL IMMUNOLOGY
卷 16, 期 11, 页码 1549-1559出版社
OXFORD UNIV PRESS
DOI: 10.1093/intimm/dxh156
关键词
influenza virus; repertoire; T cell receptor; vaccination
类别
资金
- NIAID NIH HHS [AI50900] Funding Source: Medline
Little is known about the mechanisms governing TCR repertoire selection in response to foreign antigens. Here, we evaluate the molecular features of the murine C57BL/6 (B6) TCR Vbeta repertoire directed at the NP366-374 immunodominant epitope of the influenza virus nucleoprotein. Common or 'public' beta chains are shared among individuals following either primary or secondary infection. Importantly, repertoire diversity decreases substantially after a second viral exposure due to enrichment of TCRs sharing Vbeta CDR3 loops of identical length and highly related amino acid sequences. TCRs from these secondary T cell populations possess greater overall avidity for the NP366-374/D-b complex compared to those from the primary repertoire. Thus, expansion of CD8(+) T cells expressing a favored germline Vbeta gene segment in the primary response and further selection for CDR3beta loops during the secondary response, contribute to optimization of immune recognition against certain viral epitopes.
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