期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 101, 期 44, 页码 15766-15771出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.0402824101
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资金
- NCI NIH HHS [R24 CA 095823, R24 CA095823] Funding Source: Medline
- NIDCD NIH HHS [R01 DC006685, R55 DC 05585, P01 DC 01837, P01 DC001837] Funding Source: Medline
The vestibular semicircular canals respond to angular acceleration that is integrated to angular velocity by the biofluid mechanics of the canals and is the primary origin of afferent responses encoding velocity. Surprisingly, some afferents actually report angular acceleration. Our data indicate that hair-cell/afferent synapses introduce a mathematical derivative in these afferents that partially cancels the biomechanical integration and results in discharge rates encoding angular acceleration. We examined the role of convergent synaptic inputs from hair cells to this mathematical differentiation. A significant reduction in the order of the differentiation was observed for low-frequency stimuli after gamma-aminobutyric acid type B receptor antagonist administration. Results demonstrate that gamma-aminobutyric acid participates in shaping the temporal dynamics of afferent responses.
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