期刊
JOURNAL OF NEUROSCIENCE
卷 24, 期 44, 页码 9862-9869出版社
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.3446-04.2004
关键词
alcoholism; calcium channel; conotoxin; conditioned place preference; ethanol preference; knock-out
资金
- NIAAA NIH HHS [R37 AA013588, R01 AA008117] Funding Source: Medline
N-type calcium channels are modulated by acute and chronic ethanol exposure in vitro at concentrations known to affect humans, but it is not known whether N-type channels are important for behavioral responses to ethanol in vivo. Here, we show that in mice lacking functional N-type calcium channels, voluntary ethanol consumption is reduced and place preference is developed only at a low dose of ethanol. The hypnotic effects of ethanol are also substantially diminished, whereas ethanol-induced ataxia is mildly increased. These results demonstrate that N-type calcium channels modulate acute responses to ethanol and are important mediators of ethanol reward and preference.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据