期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 23, 页码 5816-5819出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm040112r
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资金
- NCI NIH HHS [CA 17625] Funding Source: Medline
Neo-tanshinlactone (1) was isolated and synthesized for the first time and evaluated in vitro against several human cancer cell lines. Compound 1 showed significant inhibition against two ER+ human breast cancer cell lines and was 10-fold more potent and 20-fold more selective as compared to tamoxifen citrate. Compound 1 also potently inhibited an ER-, HER-2 overexpressing breast cancer cell line. Therefore, this novel compound merits further development as an anti-breast cancer drug candidate.
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