期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 47, 期 23, 页码 5605-5607出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm049503w
关键词
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With the aim to replace the natural amino acid proline by a proline mimetic structure, a cyclopent-2-enecarbonyl moiety was studied at the P2 position of prolyl oligopeptidase (POP) inhibitors. The cyclopent-2-enecarbonyl moiety proved to be an excellent proline mimetic at the P2 position of POP inhibitors. The replacement is particularly useful when increased lipophilicity is needed.
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