期刊
FEBS LETTERS
卷 577, 期 1-2, 页码 49-54出版社
WILEY
DOI: 10.1016/j.febslet.2004.09.062
关键词
adipocyte differentiation; adipogenesis; obesity; peroxisome proliferator-activated receptor gamma; fibronectin type III domain; 3T3-L1 cell
A novel gene named fad104 (factor for adipocyte differentiation-104), whose expression level quickly increased in the early stage of adipogenesis, was isolated and characterized. The deduced amino acid sequence of fad104 revealed the possible presence of a fibronectin type III domain and transmembrane domain. The expression of fad104 was detected in adipocyte differentiable 3T3-L1 cells but not observed in the non-adipogenic cell line NIH-3T3. Moreover, the ability of 3T3-L1 cells to differentiate declined with the knockdown of fad104 by RNA interference, strongly indicating that fad104 functions as a positive regulator of adipogenesis. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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