期刊
LIFE SCIENCES
卷 75, 期 25, 页码 2971-2981出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2004.05.034
关键词
muscarinic acetylcholine receptor; knockout mice; tissue distribution; parasympathetic nervous system; salivation; smooth muscle contraction; catalepsy; learning; memory
Because of the low selectivity of available ligands, pharmacological approaches to elucidate the functional difference among muscarinic acetylcholine receptor (mAChR) subtypes have been problematic. As an alternative approach, we have established a series of mutant mouse lines deficient in each mAChR subtype (mAChR KO mice). The systematic analyses of these mice have been useful in revealing the functional difference among mAChR subtypes. Here, we review our prior research on these mutant mice and also some notable findings reported by other research groups. (C) 2004 Elsevier Inc. All rights reserved.
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