期刊
VIROLOGY
卷 329, 期 1, 页码 11-17出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.virol.2004.08.011
关键词
coronavirus; interferon-gamma; interferon-beta
类别
资金
- NCI NIH HHS [CA 08921] Funding Source: Medline
- NCRR NIH HHS [RR 018229, R01 RR018229] Funding Source: Medline
- NIAID NIH HHS [AI 0543818, AI 054238, T32 AI007536, R21 AI054238, R01 AI054626, AI 007536, AI 054626, N01AI25489] Funding Source: Medline
Recent studies have shown that interferon-gamma (IFN-gamma) synergizes with IFN-alpha/beta to inhibit the replication of both RNA and DNA viruses. We investigated the effects of IFNs on the replication of two strains of severe acute respiratory syndrome-associated coronavirus (SARS-CoV). While treatment of Vero E6 cells with 100 U/ml of either IFN-beta or IFN-gamma marginally reduced viral replication, treatment with both IFN-beta and IFN-gamma inhibited SARS-CoV plaque formation by 30-fold and replication by 3000-fold at 24 h and by > 1 X 10(5)-fold at 48 and 72 h post-infection. These studies suggest that combination IFN treatment warrants further investigation as a treatment for SARS. (C) 2004 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据