期刊
APPLIED PHYSICS LETTERS
卷 97, 期 3, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3464954
关键词
biochemistry; bioelectric phenomena; biomedical electrodes; biomembrane transport; blood; cellular biophysics; drugs; electrochemical analysis; molecular biophysics; nanobiotechnology; proteins
资金
- NSF [PHY-0425897]
- Division Of Physics
- Direct For Mathematical & Physical Scien [830228] Funding Source: National Science Foundation
Direct electrical access into the cell interior is required for low-noise recording of ion channel activity, yet conventional patch clamp techniques are destructive, leading to rapid cell death, while on-chip devices have poor seal resistances. Here we report chip-based nanoscale electrodes that nondestructively incorporate into biological membranes. These consist of a metallic post with a hydrophobic band that mimics transmembrane proteins, driving insertion into the lipid membrane and forming a tight seal at the electrode-membrane interface. We demonstrate spontaneous gigaohm seals with an average seal resistance of 3.8 +/- 1.9 G Omega using red blood cells, and show the nanoband is the key attribute for high resistances. (C) 2010 American Institute of Physics. [doi:10.1063/1.3464954]
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