期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
卷 1694, 期 1-3, 页码 259-267出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2004.02.010
关键词
structural basis of fiber formation; pilus assembly; chaperone-usher pathway; bacterial pathogenesis; protein folding
资金
- NIAID NIH HHS [AI48689, AI29549] Funding Source: Medline
- NIDDK NIH HHS [DK64540, DK51406] Funding Source: Medline
Bacterial pathogens utilize the chaperone-usher pathway to assemble extracellular multi-subunit fibers essential for virulence. The periplasmic chaperone facilitates the initial folding of fiber subunits but then traps them in activated folding transition states. Chaperone dissociation releases the folding energy that drives subunit incorporation into the fiber. which grows through a pore formed by the outermembrane usher. (C) 2004 Elsevier B.V. All rights reserved.
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