期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 14, 期 22, 页码 5465-5467出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2004.09.013
关键词
GSK-3; valproate
A family of compounds based upon the chemical structure of valproate were synthesized and assayed for their ability to inhibit glycogen synthase kinase (GSK)-3 alpha and beta activity in vitro. This data is correlated to the known anti-convulsant properties of these compounds in order to determine the potential role of GSK-3 inhibition in the therapeutic efficacy of these drugs. (C) 2004 Elsevier Ltd. All rights reserved.
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