期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 12, 期 22, 页码 5997-6009出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2004.08.017
关键词
QSAR; naphthoquinone; hydrophobicity; CMR; MgVol
1,4-Naphthoquinones have already been recognized to possess a wide range of biological activities. We have developed quantitative structure activity relationships (QSAR) for different series of 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones to understand the chemical-biological interaction governing antiproliferative/cytotoxic activities against L1210 cells. QSAR results have shown that these activities of 2- or 6-substituted-5,8-dimethoxy-1,4-naphthoquinones depend largely on their hydrophobicity. (C) 2004 Elsevier Ltd. All rights reserved.
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