期刊
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
卷 143, 期 2-3, 页码 307-319出版社
ELSEVIER
DOI: 10.1016/j.resp.2004.03.020
关键词
brainstem, ponto-medullary respiratory network; model, computational; pattern of breathing, rhythm generation, eupnea, apneusis, gasping; reflexes, respiratory
资金
- NHLBI NIH HHS [HL072415-01] Funding Source: Medline
- NINDS NIH HHS [NS046062-02] Funding Source: Medline
The generation and shaping of the respiratory motor pattern are performed in the lower brainstem and involve neuronal interactions within the medulla and between the medulla and pons. A computational model of the ponto-medullary respiratory network has been developed by incorporating existing experimental data on the medullary neural circuits and possible interactions between the medulla and pons. The model reproduces a number of experimental findings concerning alterations of the respiratory pattern following various perturbations/stimulations applied to the pons and pulmonary afferents. The results of modeling support the concept that eupneic respiratory rhythm generation requires contribution of the pons whereas a gasping-like rhythm (and the rhythm observed in vitro) may be generated within the medulla and involve pacemaker-driven mechanisms localized within the medullary pre-Botzinger Complex. The model and experimental data described support the concept that during eupnea the respiration-related pontine structures control the medullary network mechanisms for respiratory phase transitions, suppress the intrinsic pacemaker-driven oscillations in the pre-BotC and provide inspiration-inhibitory and expiration-facilitatory reflexes which are independent of the pulmonary Hering-Breuer reflex but operate through the same medullary phase switching circuits. (C) 2004 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据