期刊
NEURON
卷 44, 期 4, 页码 663-676出版社
CELL PRESS
DOI: 10.1016/j.neuron.2004.10.028
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资金
- NCI NIH HHS [T32 CA09213] Funding Source: Medline
- NIDA NIH HHS [DA15383, DA15495] Funding Source: Medline
- NINDS NIH HHS [R01 NS028182, R01 NS043416, R01 NS43416, R37 NS028182, R01 NS028182-15, R01 NS043416-01A2] Funding Source: Medline
Translational repression by Drosophila Pumilio (Pum) protein controls posterior patterning during embryonic development. Here, we show that Pum is an important mediator of synaptic growth and plasticity at the neuromuscular junction (NMJ). Pum is localized to the postsynaptic side of the NMJ in third instar larvae and is also expressed in larval neurons. Neuronal Pum regulates synaptic growth. In its absence, NMJ boutons are larger and fewer in number, while Pum overexpression increases bouton number and decreases bourton size. Postsynaptic Pum negatively regulates expression of the translation factor elF-4E at the NMJ, and Pum binds selectively to the 3'UTR of elF-4E mRNA. The GluRlla glutamate receptor is upregulated in pum mutants. These results, together with genetic epistasis studies, suggest that postsynaptic Pum modulates synaptic function via direct control of elF-4E expression.
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