期刊
FEBS LETTERS
卷 577, 期 3, 页码 434-438出版社
WILEY
DOI: 10.1016/j.febslet.2004.10.042
关键词
propofol; hypoxia; hypoxia-inducible factor 1; prolyl hydroxylase; von Hippel-Lindau
Hypoxia elicits a wide range of responses that occur at different organizational levels in the body. Hypoxia is not only a signal for energy conservation and metabolic change, but triggers expression of a select set of genes. The transcription factor hypoxia-inducible factor 1 (HIF-1) is now appreciated to be a master factor of the gene induction. Although knowledge on molecular mechanisms of HIF-1 activation in response to hypoxia is accumulating, the molecular mechanism of maintenance of HIF-1 activity under normoxic conditions remains to be elucidated. We demonstrate that the intravenous anesthetic propofol reversibly inhibits HIF-1 activity and the gene expression mediated by HIF-1 by blocking the synthesis of the HIF-1alpha subunit under 20% or 5% O-2 conditions, but not under 1% O-2 conditions. (C) 2004 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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