期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 10, 期 22, 页码 5697-5705出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200305731
关键词
DNA damage; DNA repair; DNA; hairpin structures; RNA; UV irradiation
DNA and RNA hairpins, which represent well-folded oligonucleotide structures, were irradiated and the amount of damaged hairpins was directly quantified by using ion-exchange HPLC. The types of photoproducts formed in the hairpins were determined by ESI-HPLC-MS/MS experiments. Irradiation of hairpins with systematically varied sequences and conformations (A versus B) revealed remarkable differences regarding the amount of photolesions formed. UV-damage formation is, therefore, a strongly sequence and conformation dependent process.
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