期刊
FEBS LETTERS
卷 577, 期 3, 页码 478-482出版社
WILEY
DOI: 10.1016/j.febslet.2004.10.050
关键词
disintegrin; integrin antagonist; collagen receptor; KTS-peptide; cell adhesion
资金
- NCI NIH HHS [R01 CA10014501A1] Funding Source: Medline
KTS-disintegrins are a subfamily of short monomeric disintegrins that are potent and selective inhibitors of alpha1beta1 integrin. The amino acid sequence of the new KTS-disintegrin, viperistatin, differs from previously characterized obtustatin in three residues at position 24 (within the integrin binding loop), 38 (hydrophobic core) and 40 (C-terminal region). Noteworthy, viperistatin is about 25-fold more potent than obtustatin inhibiting the binding of this integrin to collagen IV. Synthetic peptides representing the full-length of integrin-binding loops of these disintegrins showed that the Leu24/Arg substitution appears to be partly responsible for the increased inhibitory activity of viperistatin over obtustatin. (C) 2004 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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