Late-onset optic pathway tumors in children with neurofibromatosis 1

Identification of new optic pathway tumors (OPTs) and progression of pre-existing OPTs in children with neurofibromatosis 1 (NF1) have been reported infrequently after age 6. The authors present eight children with NF1 ( mean age 12.2 years) seen in three NF1 centers who had either late-onset ( four of eight) or late-progressive ( seven of eight) OPT. Continued monitoring of individuals with NF1 into adulthood for the development of OPTs and for progression of known OPTs is warranted.