期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 126, 期 46, 页码 15067-15073出版社
AMER CHEMICAL SOC
DOI: 10.1021/ja046280q
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资金
- NIGMS NIH HHS [T32 GM008449] Funding Source: Medline
Replacing the ethylenediamine portion of aminoethylglycine peptide nucleic acids (aegPNAs) with one or more (S,S)-trans-cyclopentane diamine units significantly increases binding affinity and sequence specificity to complementary DNA, making these modified PNAs ideal for use as nucleic acid probes in genomic analysis. The synthesis and study of this new class of PNAs (tcypPNAs) is described in which trans-cyclopentane diamine has been incorporated into several positions, and in varying number, within PNA backbones of mixed-base sequences.
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