期刊
SCIENCE
卷 306, 期 5701, 页码 1568-1571出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1099513
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资金
- NCI NIH HHS [R01 CA87958, K22 CA90518, CA95103] Funding Source: Medline
- NIDDK NIH HHS [R01 DK58] Funding Source: Medline
Epithelial cancers are believed to originate from transformation of tissue stem cells. However, bone marrow-derived cells (BMDCs), which are frequently recruited to sites of tissue injury and inflammation, might also represent a potential source of malignancy. We show that although acute injury, acute inflammation, or transient parietal cell loss within the stomach do not lead to BMDC recruitment, chronic infection of C57BL/6 mice with Helicobacter, a known carcinogen, induces repopulation of the stomach with BMDCs. Subsequently, these cells progress through metaplasia and dysplasia to intraepithelial cancer. These findings suggest that epithelial cancers can originate from marrow-derived sources and thus have broad implications for the multistep model of cancer progression.
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