4.8 Article

Dynamical resonance can account for seasonality of influenza epidemics

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NATL ACAD SCIENCES
DOI: 10.1073/pnas.0407293101

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demographic stochasticity; disease dynamics; susceptible infectious recovered (SIR); immunity

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  1. NIGMS NIH HHS [1-R01-GM60729-01] Funding Source: Medline

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influenza incidence exhibits strong seasonal fluctuations in temperate regions throughout the world, concentrating the mortality and morbidity burden of the disease into a few months each year. The cause of influenza's seasonality has remained elusive. Here we show that the large oscillations in incidence may be caused by undetectably small seasonal changes in the influenza transmission rate that are amplified by dynamical resonance.

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