期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 32, 期 -, 页码 1087-1089出版社
PORTLAND PRESS
DOI: 10.1042/BST0321087
关键词
chemotherapy; nuclear factor kappa B (NF-kappa B); post-translational modification; RelA; transcription; UV light
Stimulation with diverse agents activates the NF-kappaB (nuclear factor kappaB) transcription factor, affecting inflammatory and immune responses, proliferation, differentiation, apoptosis and tumourigenesis. Determining how NF-kappaB elicits such distinct responses is essential to understanding NF-kappaB function in diseased tissues. Recent developments illustrating that post-translational modification of NF-kappaB subunits influences their nuclear role are discussed. These observations suggest that diagnosis and new therapies based on reprogramming NF-kappaB activity could be more efficient than total NF-kappaB inhibition.
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