期刊
JOURNAL OF APPLIED PHYSIOLOGY
卷 97, 期 6, 页码 2347-2353出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/japplphysiol.00435.2004
关键词
tubulogenesis; cell migration; fibroblast growth factor signaling; air sacs; zona pellucida domain; containing proteins; adherens junction remodeling
Recent comparative studies have shown that, in many instances, the genetic network underlying the development of distinct organ systems is similar in invertebrate and vertebrate organisms. Genetically well-characterized, simple invertebrate model systems, such as Caenorhabditis elegans and Drosophila melanogaster, can thus provide useful insight for understanding more complex organ systems in vertebrates. Here, we summarize recent progress in the genetic analysis of tracheal development in Drosophila and compare the results to studies aimed at a better understanding of lung development in mouse and man. Clearly, both striking similarities and important differences are apparent, but it might still be too early to conclude whether the former or the latter prevail.
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