期刊
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
卷 24, 期 6, 页码 562-566出版社
ELSEVIER
DOI: 10.1016/j.ijantimicag.2004.07.011
关键词
Clostridium difficile; antibiotics; mortality; risk factors
The objective of this study was to evaluate the risk of certain patient co-morbidities and antibiotics in the development of Clostridium difficile-associated diarrhoea (CDAD). Hospitalized patients developing CDAD during a specified period were compared with a cohort of patients, matched by age, without a diagnosis of CDAD, who were hospitalized during the same time period. Data collection included demographics, hospital ward, co-morbid conditions, antibiotics received, and mortality. Gender and age were similar in both groups. Comorbid conditions significantly associated with the case group included cancer and COPD. The most commonly prescribed antibiotics in the case versus control group included levofloxacin, intravenous vancomycin, clindamycin, and piperacillin/tazobactam. The case group was associated with a higher mortality rate. Published by Elsevier B.V. and the International Society of Chemotherapy.
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