期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 157, 期 1-2, 页码 147-152出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2004.08.043
关键词
HIV; diffusion; spectroscopy; cognition; inflammation
资金
- NIDA NIH HHS [T32 DA07316, K24 DA16170] Funding Source: Medline
- NINDS NIH HHS [R01 NS38834] Funding Source: Medline
- PHS HHS [K0216991] Funding Source: Medline
Diffusion-weighted imaging (DWI) measures brain water diffusion that is sensitive to microscopic brain injury. A total of 11 HIV seropositive patients were compared to 14 seronegative subjects using DWI, proton magnetic resonance spectroscopy (H-1 MRS), and neuropsychological tests. The apparent diffusion coefficient (ADC) was significantly increased in the HIV patients, primarily in the frontal white matter (FWM; +5%, p=0.01). Diffusivity correlated positively with the glial marker myo-inositol (r=0.5, p=0.008) and negatively with cognitive performance (NPZ-8 composite score; r=-0.43, p=0.05). These findings suggest increased brain water diffusion may reflect increased glial activation or inflammation, which in turn, may contribute to the cognitive deficits in HIV patients. (C) 2004 Elsevier B.V. All rights reserved.
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