期刊
APPLIED PHYSICS LETTERS
卷 95, 期 25, 页码 -出版社
AMER INST PHYSICS
DOI: 10.1063/1.3275719
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资金
- U.S. Army Research Laboratory
- U.S. Army Research Office [W911 NF-07-1-0618]
- DARPA-DSO
- AFOSR
- NIH [P41]
Free-standing silk films are useful materials to manufacture nanopatterned optical elements and to immobilize bio-dopants such as enzymes while maintaining their biological activity. These traits were combined by incorporating hemoglobin into free-standing silk diffraction gratings to fabricate chemically responsive optofluidic devices responsive to ambient gas conditions, constituting a simple oxygen sensor. This type of self-analyzing optical system is enabled by the unique ability to reproduce high-fidelity optical structures in silk while maintaining the activity of entrapped proteins such as hemoglobin. These bioactive optical devices offer a direct readout capability, adding utility into the bioresponsive material arena. (C) 2009 American Institute of Physics. [doi:10.1063/1.3275719]
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