期刊
MEDICAL MYCOLOGY
卷 42, 期 6, 页码 531-541出版社
OXFORD UNIV PRESS
DOI: 10.1080/1369378042000193194
关键词
C albicans; cytokines; epithelial cells; fibroblasts
资金
- NIDCR NIH HHS [R01 DE13986] Funding Source: Medline
Oral epithelial cells are primary targets of Candida albicans in the oropharynx and may regulate the inflammatory host response to this pathogen. This investigation studied the mechanisms underlying interleukin-1alpha (IL-1alpha) release by oral epithelial cells and the role of IL-1alpha in regulating the mucosal inflammatory response to C albicans. Infected oral epithelial cells released processed IL-1alpha protein in culture supernatants. The IL-1alpha generated was stored intracellularly and was released upon cell lysis. This was further supported by the fact that different C albicans strains induced variable IL-1alpha release, depending on their cytolytic activity. IL-1alpha from C albicans-infected oral epithelial cells upregulated proinflammatory cytokine secretion (IL-8 and GM-CSF) in uninfected oral epithelial or stromal cells. Our studies suggest that production of IL-1alpha, IL-8 and GM-CSF may take place in the oral mucosa in response to lytic infection of epithelial cells with C albicans. This process can act as an early innate immune surveillance system and may contribute to the clinicopathologic signs of infection in the oral mucosa.
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