期刊
BRITISH JOURNAL OF PHARMACOLOGY
卷 143, 期 7, 页码 899-907出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bjp.0705940
关键词
lymphocytes; multidrug transporters; P-glycoprotein
I Multidrug transporters play a dual role in haematopoietic cells, mediating the efflux of xenobiotics and regulating cell migration. 2 For several reasons including the lack of specific antibodies, reports of multidrug transporter distribution on lymphocytes conflict. Murine B cells have been reported to completely lack transporter activity. 3 Through analysis of parental and 'knockout' mice we show that, contrary to previous studies, murine B and T lymphocytes possess at least three active multidrug transporters and also a hitherto unrecognised drug-specific import activity. 4 Surprisingly, the drug specificity of P-glycoprotein appears cell type dependent. The data indicate that a range of developmentally regulated, multidrug transporters can impose a barrier to treatment of immune disorders.
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