期刊
MICROBES AND INFECTION
卷 6, 期 15, 页码 1361-1367出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2004.08.015
关键词
endotoxin; TLR; IRF; signaling
资金
- NCRR NIH HHS [RR14466] Funding Source: Medline
- NIAID NIH HHS [AI52455] Funding Source: Medline
- NIGMS NIH HHS [GM54060] Funding Source: Medline
Bacterial lipopolysaccharides are recognized in mammals by a receptor complex composed of CD14, Toll-like receptor (TLR)-4 and MD-2. Transduction of signaling is achieved following the recruitment of a combination of four Toll-interleukin-1 resistance (TIR)-domain-containing adapter molecules, which provide a structural platform enabling the recruitment and activation of downstream effectors essential for pathway-specific transcription factor activation and inflammatory gene expression. (C) 2004 Published by Elsevier SAS.
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