期刊
NEUROPHARMACOLOGY
卷 47, 期 8, 页码 1205-1216出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2004.08.021
关键词
epilepsy; carbenoxolone; GEPR-3s; GEPR-9s; gap junction; connexin; audiogenic seizures
Carbenoxolone (CBX), the succinyl ester of glycyrrhetinic acid. is an inhibitor of gap junctional intercellular commuication. Systemic administration of CBX was able to decrease the seizure severity score and to increase the latency time of seizure onset in genetically epilepsy prone rats (GEPRs). In particular, intravenous or intraperitoneal administration of carbenoxolone (5-30 mg/ kg) produced a dose-dependent and significant reduction in the clonic and ionic phases of the audiogenic seizures in GEPRs. The anticonvulsant doses were not associated with an impairment of motor coordination. The bilateral microinjection of CBX (0.001-0.50 mug/0.5 mul) into the inferior colliculi, the substantia nigra (pars reticulata or compacta) and inferior oviary complex was able to reduce the seizure severity score in a dose-dependent manner. The anticonvulsant effects were longer lasting after focal microinjection than after systemic administration. No anticonvulsant effects were observed following focal bilateral microinjections of glycyrrhizin into the same brain areas where CBX was shown to be effective. (C) 2004 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据