期刊
CURRENT OPINION IN IMMUNOLOGY
卷 16, 期 6, 页码 732-737出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2004.09.016
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Noncovalent drug presentation leads to the activation of drug-specific T cells. In some patients with hypersensitivity, such a response occurs within hours even upon the first exposure to the drug. Thus, the reaction to the drug might not be due to a classical, primary response, but rather mediated by existing, preactivated T cells that are cross specific for the drug, and have an additional (peptide) specificity as well.
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