期刊
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
卷 287, 期 6, 页码 H2535-H2544出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00889.2003
关键词
inflammation; computational model; microcirculation; spatial heterogeneity
Inherent in the inflammatory response to sepsis is abnormal microvascular perfusion. Maldistribution of capillary red blood cell (RBC) flow in rat skeletal muscle has been characterized by increased 1) stopped-flow capillaries, 2) capillary oxygen extraction, and 3) ratio of fast-flow to normal-flow capillaries. On the basis of experimental data for functional capillary density (FCD), RBC velocity, and hemoglobin O-2 saturation during sepsis, a mathematical model was used to calculate tissue O-2 consumption ((V)over dotO(2)), tissue PO2 (P-t) profiles, and O-2 delivery by fast-flow capillaries, which could not be measured experimentally. The model describes coupled capillary and tissue O-2 transport using realistic blood and tissue biophysics and three-dimensional arrays of heterogeneously spaced capillaries and was solved numerically using a previously validated scheme. While total blood flow was maintained, capillary flow distribution was varied from 60/30/10% (normal/fast/stopped) in control to 33/33/33% (normal/fast/stopped) in average sepsis (AS) and 25/25/50% (normal/fast/stopped) in extreme sepsis (ES). Simulations found approximately two- and fourfold increases in tissue (V)over dotO(2) in AS and ES, respectively. Average (minimum) P-t decreased from 43 (40) mmHg in control to 34 (27) and 26 (15) mmHg in AS and ES, respectively, and clustering fast-flow capillaries (increased flow heterogeneity) reduced minimum P-t to 14.5 mmHg. Thus, although fast capillaries prevented tissue dysoxia, they did not prevent increased hypoxia as the degree of microvascular injury increased. The model predicts that decreased FCD, increased fast flow, and increased (V)over dotO(2) in sepsis expose skeletal muscle to significant regions of hypoxia, which could affect local cellular and organ function.
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