期刊
AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 80, 期 6, 页码 1706S-1709S出版社
AMER SOC CLINICAL NUTRITION
DOI: 10.1093/ajcn/80.6.1706S
关键词
rickets; osteomalacia; osteoporosis; calcium absorption; fractures; serum 25-hydroxyvitamin D-3
Serum 25-hydroxyvitamin D-3 [25(OH)D-3] concentrations are currently recognized as the functional status indicator for vitamin D. Evidence is reviewed that shows that serum 25(OH)D-3 concentrations of < 80 nmol/L are associated with reduced calcium absorption, osteoporosis, and increased fracture risk. For typical older individuals, supplemental oral intakes of similar to1300 IU/d are required to reach the lower end of the optimal range. Evidence of substantial problems in routine clinical measurement of serum 25(OH)D-3 concentrations among patients is cited. There is great need for standardization and improved reproducibility and sensitivity of measurements of serum 25(OH)D-3 concentrations.
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