期刊
MEMORIAS DO INSTITUTO OSWALDO CRUZ
卷 99, 期 8, 页码 873-876出版社
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762004000800015
关键词
tungiasis; Tunga penetrans; therapy; ivermectin; randomized controlled trial; Brazil
Tungiasis is an ectoparasitosis causing considerable pathology in endemic areas. Standard therapy consists of removing the embedded parasite with a sterile needle. There is no effective chemotherapy at hand. To fill this gap, a double-blinded randomized controlled trial with oral ivermectin was conducted. A total of 54 individuals (27 in the placebo group, 27 in the ivermectin group) was followed tip for seven days. They presented a total of 192 lesions. Patients received either ivermectin (300 mug/kg body weight at a single dose, repeated after 24 h) or placebo. Outcome measures included the clinical stage of lesion, presence of erythema, pain, itching signs of viability; of the parasite, and total lysis of flea. The ratio of fleas with total lysis per total number of fleas was slightly higher in the ivermectin group; however this difference was not statistically significant. There was no significant difference in any of the other outcome measures between the treatment and the placebo group. The results show that oral ivermectin is without any clinically significant efficacy against embedded sand fleas at the dose given.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据