期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 5, 期 6, 页码 485-494出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201043376553
关键词
MRI; targeted contrast agents; receptor imaging; specific binding
资金
- NCI NIH HHS [P50 CA 103175, P20 CA86346] Funding Source: Medline
- NINDS NIH HHS [R01 NS-045062] Funding Source: Medline
Over the past decade MR (magnetic resonance) imaging has emerged as one of the major modalities for noninvasive functional imaging. Recent advances in the development of targeted MR contrast agents have added significantly to the capabilities of MR imaging. In particular, the use of targeted contrast agents to report on the expression of cell surface receptors, combined with the functional capabilities of MR imaging, together provide unique opportunities to understand receptor-mediated pathways. In this article we have reviewed current MRI strategies used to visualize receptor expression, the potential advantages and drawbacks of these strategies, and novel areas of focus for the future.
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