期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 89, 期 12, 页码 5920-5926出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2003-031719
关键词
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资金
- NCI NIH HHS [R01-CA770403] Funding Source: Medline
- NIA NIH HHS [AG 04673] Funding Source: Medline
- NIDDK NIH HHS [DK 44995, DK 51345] Funding Source: Medline
Little is known about the descriptive epidemiology of androgen deficiency. In this study, we sought to address this issue by providing estimates of the crude and age-specific prevalence and incidence rates of androgen deficiency in a randomly sampled population-based cohort of middle-aged and older men. Data on androgen deficiency ( defined using both signs/symptoms plus total and calculated free testosterone) were available for n = 1691 ( baseline) and n = 1087 ( follow-up) men from the Massachusetts Male Aging Study. Crude and age-specific prevalence and incidence rates were calculated. Based on these estimates, projections for the number of cases of androgen deficiency in the 40- to 69-yr-old U. S. male population were computed. Estimates of the crude prevalence of androgen deficiency at baseline and follow-up were 6.0 and 12.3%, respectively. Prevalence increased significantly with age. From baseline age-specific prevalence data, it is estimated that there are approximately 2.4 million 40- to 69-yr-old U. S. males with androgen deficiency. The crude incidence rate of androgen deficiency was 12.3 per 1,000 person-years, and the rate increased significantly (P< 0.0001) with age. Based on these incidence data, we can expect approximately 481,000 new cases of androgen deficiency per year in U. S. men 40 - 69 yr old.
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