期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 19, 期 12, 页码 2033-2040出版社
WILEY
DOI: 10.1359/JBMR.040907
关键词
low-density lipoprotein receptor-related proteins 5 and 6; Lrp5; Lrp6; osteoporosis; bone densitometry; knockout mice; Wnt; limb development
Humans and mice lacking Lrp5 have low BMD. To evaluate whether Lrp5 and Lrp6 interact genetically to control bone or skeletal development, we created mice carrying mutations in both Lrp5 and the related gene Lrp6. We found that compound mutants had dose-dependent deficits in BMD and limb formation, suggesting functional redundancy between these two genes in bone and limb development.
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