期刊
QSAR & COMBINATORIAL SCIENCE
卷 23, 期 10, 页码 891-894出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/qsar.200420034
关键词
three-component coupling; propargylamine; solventless; microwave
Direct Grignard type addition of terminal alkynes to in situ generated imines, from aldehydes and amines, occurs under microwave irradiation using CuBr alone in a one-pot operation. This solventless approach provides ready access to propargylamines and is applicable both to aromatic and aliphatic aldehydes.
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