期刊
MICROBES AND INFECTION
卷 6, 期 15, 页码 1388-1394出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2004.08.019
关键词
Toll-like receptor; innate immunity; adaptive immunity; dendritic cells
A group of type I transmembrane proteins, Toll-like receptors (TLRs) discriminate various microorganism-associated molecular structures that can function as immune adjuvants. Each TLR signaling has an overlapping but distinct function, which largely depends on intracellular adaptor molecules. Clarifying the functions and signaling of TLRs should provide us with critical information for manipulating the host defense mechanism. (C) 2004 Elsevier SAS. All rights reserved.
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