期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 52, 期 12, 页码 1495-1496出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.52.1495
关键词
Pogostemon cablin; labiatae; sesquiterpene hydroperoxide; trypanocidal constitutent; Topanosoma cruzi
Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 mum (1), 1.7mum (2) and 1.7 mum (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC > 200mum).
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