期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 52, 期 12, 页码 1492-1494出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.52.1492
关键词
Vitex trifolia; Verbenaceae; norditerpene aldehyde; trypanocidal cruzi
Trypanocidal constituents of the fruits of Vitex trifolia were investigated. Activity-guided isolation of the acetone extract resulted in the isolation of two new norditerpene aldehydes, 1 and 2, together with five known diterpenes: vitexifolin E (3), vitexifolin F (4), vitexilactone (5), 6-acetoxy-9-hydroxy-13(14)-labden-16,15-olide (6), and previtexilactone (7). In vitro minimum lethal concentrations of the isolated compounds against epimastigotes of Trypanosoma cruzi were 11mum (1), 36mum (2),34mum (3),34mum (4), 66mum (5), 66mum (6), and >265mum (7).
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