期刊
BEHAVIORAL NEUROSCIENCE
卷 118, 期 6, 页码 1317-1323出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.118.6.1317
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资金
- NIMH NIH HHS [MH K02-001714, MH R01-40826] Funding Source: Medline
Dopamine in the medial preoptic area (MPOA) facilitates copulation in male rats, and nitric oxide (NO) regulates basal and female-stimulated MPOA dopamine release. Microinjection of L-nitro-arginine methyl ester (L-NAME, an NO synthesis inhibitor) into the MPOA blocked copulation in naive rats and impaired copulation in sexually experienced males. In other naive rats, L-NAME or saline was microinjected into the MPOA before each of 7 daily exposures to a receptive female placed over their cage. In a drug-free test on Day 8, copulation by L-NAME-treated rats was similar to that of unexposed controls and was impaired relative to saline-treated males. Therefore, NO in the MPOA is important for copulation and stimulus sensitization in male rats.
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